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Identification

CAS Number

474645-27-7

Name

MMAE, vedotin

Synonyms

474645-27-7 L-Valinamide, N-methyl-L-valyl-N-amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1--4-oxo butyl]-N-methyl- MMAEMonomethyl auristatin E Monomethylauristatin EN-Methyl-L-valyl-N-amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valin amid N-Methyl-L-valyl-N-amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valin amide N-Méthyl-L-valyl-N-amino}-1-méthoxy-2-méthyl-3-oxopropyl]-1-pyrrolidinyl}-3-méthoxy-5-méthyl-1-oxo-4-heptanyl]-N-méthyl-L-valin amide UNII-V7I58RC5EJV7I58RC5EJ(2S)-N-amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide(S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2 4Q5MFCD22124498 MMAE (Monomethyl auristatin E)Monomethyl auristatin E (MMAE)N-methyl-L-valyl-N-amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1--4-oxobutyl]-N-methyl-L-valinamideN-Methyl-L-Valyl-N-amino}-1-Methoxy-2-Methyl-3-Oxopropyl]pyrrolidin-1-Yl}-3-Methoxy-5-Methyl-1-Oxoheptan-4-Yl]-N-Methyl-L-ValinamideUNII:V7I58RC5EJUntitled DocumentVedotin; MMAE

SMILES

CC(C)((CC(=O)N1CCC1((C)C(=O)N(C)(c2ccccc2)O)OC)OC)N(C)C(=O)(C(C)C)NC(=O)(C(C)C)NC

StdInChI

InChI=1S/C39H67N5O7/c1-13-25(6)34(43(10)39(49)33(24(4)5)42-38(48)32(40-9)23(2)3)30(50-11)22-31(45)44-21-17-20-29(44)36(51-12)26(7)37(47)41-27(8)35(46)28-18-15-14-16-19-28/h14-16,18-19,23-27,29-30,32-36,40,46H,13,17,20-22H2,1-12H3,(H,41,47)(H,42,48)/t25-,26+,27+,29-,30+,32-,33-,34-,35+,36+/m0/s1

StdInChIKey

DASWEROEPLKSEI-UIJRFTGLSA-N

Molecular Formula

C39H67N5O7

Molecular Weight

717.979 

MDL Number

MFCD22124498

Properties

Appearance

White powder

Melting Point

＞90°C

Safety Data

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our MMAE, vedotin CAS 474645-27-7

Introduce

MMAE is widely used as a cytotoxic component to make antibody-drug conjugates (ADCs) to treat cancer. Due to its toxicity, it cannot be used as a drug by itself but rather linked to monoclonal antibodies (MABs). It is an effective anti-mitotic drug. It is a new type of drug synthesized from an extremely toxic polypeptide extracted from Aplysia in the Indian Ocean. It has a strong anti-tumor effect and is an anti-microbial drug like vinblastine. It is a tube drug, but its toxicity is about 200 times that of vinblastine. Because it is too toxic and cannot be used by intravenous drip, it can only exert its lethality in ADC drugs. It currently shows potent in vitro and in vivo activity against a variety of lymphomas, leukemias and solid tumors in preclinical studies.

Identification Methods

HNMR, HPLC

Purity

98% min

Shelf Life

2 years

Storage

Under room temperature away from light

Known Application

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of Aplysia toxin 10, which acts as a potent mitotic inhibitor by inhibiting tubulin polymerization.

Links

This product is developed by our R&D company Caming Pharmaceutical Ltd (https://www.caming.com/).

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