- Identification

- Properties

- Safety Data

- Specifications & Other Information

- Links

- Quick Inquiry

Identification

CAS Number

1263166-90-0

Name

BCN-OH

Synonyms

(1R,8S,9s)-Bicyclonon-4-in-9-ylmethanol

(1R,8S,9s)-Bicyclonon-4-yn-9-ylmethanol

(1R,8S,9s)-Bicyclonon-4-yn-9-ylméthanol

(1α,8α,9β)-Bicyclonon-4-yne-9-methanol

1263166-90-0

9-Hydroxymethylbicyclononyne

BCN-OH

Bicyclonon-4-yne-9-methanol, (1R,8S)-

endo-9-Hydroxymethylbicyclonon-4-yne

MFCD26142970

SMILES

OC12CCC#CCC12

StdInChI

InChI=1S/C10H14O/c11-7-10-8-5-3-1-2-4-6-9(8)10/h8-11H,3-7H2/t8-,9+,10-

StdInChIKey

NSVXZMGWYBICRW-ILWJIGKKSA-N

Molecular Formula

C10H14O

Molecular Weight

150.221

Beilstein Registry Number

21037713

MDL Number

MFCD26142970

Properties

Appearance

White to off-white powder

Safety Data

Symbol

Signal Word

Warning

MSDS Download

Specifications and Other Information of Our BCN-OH CAS 1263166-90-0

Identification Methods

HNMR, GC

Purity

98% min

Shelf Life

1 year

Storage

Store at 2~8℃ for long time

Known Application

BCN-OH, a strained alkyne building block, is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN. The TPP group is a reactive sulfenic acid probe that targets mitochondria. It is primarily used in copper-free click chemistry and is commonly used for protein and antibody labeling and the preparation of bioprobes.1. Biomolecule Modification and LabelingProtein/Antibody Labeling: BCN-OH derivatives are conjugated to azide-modified proteins or antibodies for imaging, diagnostics, or drug-drug conjugates (ADCs).Nucleic Acid and Carbohydrate Labeling: Conjugation to azide-modified oligonucleotides or polysaccharides for tracking or functionalization.2. Drug Delivery and NanomaterialsDrug conjugates: They can serve as carriers for linking small molecule drugs to targeting vectors (e.g., antibodies or peptides) via click reactions.Nanoparticle Surface Modification: BCN-OH can be used to modify the surfaces of polymers, liposomes, or quantum dots, and then conjugated with azides for precise targeted delivery.

3. Materials SciencePolymer Chemistry: Used as a monomer or cross-linker to construct functionalized polymers or hydrogels.Surface Modification: BCN groups are introduced onto glass, metal, and polymer surfaces, followed by click reactions with azides to achieve surface functionalization (e.g., biosensors and chips).4. Diagnostics and ImagingFluorescent Probes: Highly sensitive probes are obtained through click coupling with azide-containing fluorophores.Radioactive Probes: In molecular imaging, they are coupled with azide-containing radiolabels for PET/SPECT imaging.5. Research ToolsMetabolic Labeling: Azide-modified compounds (e.g., azidosugars) are introduced into cellular metabolism and then coupled with BCN to track cellular metabolic pathways.Protein Interaction Studies: Used as a cross-linking reagent to help immobilize or pull down target complexes.

General View of Documents

GC of BCN-OH CAS 1263166-90-0

HNMR of BCN-OH CAS 1263166-90-0

Links

This product is developed by our R&D company Caming Pharmaceutical Limited (http://www.caming.com/).

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you shortly. https://www.watson-int.com/bcn-oh-cas-1263166-90-0/