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4-Methylbenzenesulfonic Anhydride CAS 4124-41-8
- Identification

- Properties

- Safety Data

- Specifications & Other Information

- Links

- Quick Inquiry

Identification

CAS Number

4124-41-8

Name

4-Methylbenzenesulfonic Anhydride

Synonyms

1,3-bis(4-methylphenyl)-1,1,3,3-tetraoxo-1λ~6~,3λ~6~-dithioxane223-926-94-Toluenesulfonic anhydrideMFCD00008548p-Toluenesulfonic Anhydridep-tolylsulfonyl 4-methylbenzenesulfonate(4-methylphenyl)sulfonyl 4-methylbenzenesulfonate4-methyl benzenesulfonic anhydride4-methylbenzenesulfonic anhydride4-Methylbenzenesulfonic anhydride; Tosic anhydride4-Methylbenzenesulfonicanhydride4-methylbenzenesulfonyl 4-methylbenzene-1-sulfonate4-METHYLBENZENESULFONYL 4-METHYLBENZENESULFONATE4-Methylbenzenesulphonic anhydride, Tosic anhydride4-Methylbenzenesulphonic anhydride; Tosic anhydride4-Toluenesulfonic acid anhydride4-Toluenesulphonic anhydrideBenzenesulfonic acid, 4-methyl-, anhydridep-methylbenzenesulfonyl (tosylate)p-Toluene sulfonic anhydridep-Toluenesulfonicanhydridep-toluenesulfonicanhydride(rs20007372)p-Toluenesulphonic anhydrideP-TolueneSulphonicAnhydridep-​toluenesulfonic anhydridetoluene-4-sulfonic anhydrideToluene-4-sulphonic anhydridetoluene-p-sulphonic anhydrideTosic anhydride

SMILES

Cc1ccc(S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2)cc1

StdInChI

InChI=1S/C14H14O5S2/c1-11-3-7-13(8-4-11)20(15,16)19-21(17,18)14-9-5-12(2)6-10-14/h3-10H,1-2H3

StdInChIKey

PDVFSPNIEOYOQL-UHFFFAOYSA-N

Molecular Formula

C14H14O5S2

Molecular Weight

326.381

EINECS

223-926-9

MDL Number

MFCD00008548

Properties

Appearance

Off-white solid

Melting Point

118°C ~128°C

Safety Data

Symbol

GHS05

Signal Word

Danger

Hazard statements

H314

Precautionary Statements

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our 4-Methylbenzenesulfonic Anhydride CAS 4124-41-8

Identification Methods

HNMR, HPLC

Purity

98% min

Shelf Life

2 years

Storage

Store at room temperature, in container tightly sealed; Protect from light. Store in a dry place at 16° for a long time. The product is easy to absorb moisture and needs to be stored with desiccant.

Known Application

- Organic synthesis - strong dehydration condensation agentEsterification reaction Activate carboxyl to accelerate ester formationPeptide bond formation Mildly catalyze amino acid condensationSulfonylation protecting group Introduce -SO₂Tol group to protect amino/hydroxyl groups

- Synthesis of pharmaceutical intermediatesAntiviral drugs, synthesis of acyclovir side chain Reaction yield increased ​​>15%​​(compared with methanesulfonyl chloride method)Antitumor drugs, construction of temozolomide pyrimidine ring Avoid the use of highly toxic phosgeneAntibiotics, modification of β-lactam ring C3 position Selectivity ​​>90%​​(such as cefixime precursor)

- Polymer material modificationPolyester catalyst Replacement of antimony oxide (reducing heavy metals) Material transmittance ​​↑8%​​, melting point stability improvedEpoxy resin curing accelerator Activate curing reaction at low temperature (60℃) Curing time shortened ​​40%​​Ionic liquid synthesis Preparation of sulfonic acid ionic liquid Conductivity ​​≥15 mS/cm​​ (fuel cell electrolyte)

Key reaction characteristics

- Reaction activity is higher than p-toluenesulfonyl chloride, shortening the reaction time

- Selectivity, preferentially reacting with primary alcohols/primary amines to reduce secondary group side reactions

- Byproduct, water-soluble toluenesulfonic acid is generated, which is easy to separate and purify

- Stability, needs to be stored in a dry and sealed state (decomposed in water), and operation requires strict humidity control

General View of Documents

HNMR of 4-Methylbenzenesulfonic Anhydride CAS 4124-41-8

Links

This product is developed by our R&D company Warshel Chemical Ltd (https://www.warshel.com/).

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you shortly. https://www.watson-int.com/4-methylbenzenesulfonic-anhydride-cas-4124-41-8/

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