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Identification
CAS Number
86030-08-2
Name
BTB-1
Synonyms
4-Chlor-2-nitro-1-(phenylsulfonyl)benzol 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene 4-Chloro-2-nitro-1-(phénylsulfonyl)benzène 4-Chloro-2-nitrophenyl phenyl sulfone86030-08-2 Benzene, 4-chloro-2-nitro-1-(phenylsulfonyl)- BTB-1 1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid1-(benzenesulfonyl)-4-chloro-2-nitrobenzene1-Benzenesulfonyl-4-chloro-2-nitrobenzene1-Benzenesulfonyl-4-chloro-2-nitro-benzene2-Benzenesulfonyl-5-chloronitrobenzene4-chloro-2-nitro-1-(phenylsulfonyl)-benzene4-Chloro-2-nitro-1-(phenylsulphonyl)benzene4-Chloro-2-nitrodiphenyl sulfone4-Chloro-2-nitrodiphenyl sulfone; 1-(Benzenesulfonyl)-4-chloro-2-nitrobenzene4-Chloro-2-nitrodiphenyl sulphone4-Chloro-2-nitrodiphenylsulfone87395-64-0 BTB 1BTB1MFCD00052250 N-(1-Hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamideNSC 156750; NSC 658180SS-5790
SMILES
c1ccc(cc1)S(=O)(=O)c2ccc(cc2(=O))Cl
StdInChI
InChI=1S/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H
StdInChIKey
VZDUQPHKUBZMLW-UHFFFAOYSA-N
Molecular Formula
C12H8ClNO4S
Molecular Weight
297.714
Properties
Appearance
White to off-white
Structure
Structure of BTB-1 CAS 86030-08-2
Safety Data
Symbol
Signal Word
Warning
WGK Germany
3
MSDS Download
Specifications and Other Information of Our
Identification Methods
HNMR, HPLC
Water
Loss on Drying
Residue on Ignition
Single Impurity
Total Impurities
Shelf Life
2 years
Storage
store at room temperature away from light; Sealed in dry.
Known Application
BTB-1 CAS 86030-08-2 also called 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE, is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 ÎĽM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. BTB-1 shows cell toxicity with an EC50 values of 35.8ÎĽM. HeLa cells treated with 50ÎĽM BTB1 reveals severe defects inspindle morphology and chromosome alignment.Treatment with high concentrations of BTB-1 does not result in elongated spindles.
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Links
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