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Identification
CAS Number
1440964-89-5
Name
PLB-1001
Synonyms
1,2,4-Triazolopyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-- 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-triazolopyridazin 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-triazolopyridazine 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-triazolopyridazine 1440964-89-5 6-(1-cyclopropylpyrazol-4-yl)-3--triazolopyridazineBozitinibBozitinib (PLB-1001)
SMILES
1,2,4-Triazolopyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-- 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-triazolopyridazin 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-triazolopyridazine 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-triazolopyridazine 1440964-89-5 6-(1-cyclopropylpyrazol-4-yl)-3--triazolopyridazineBozitinibBozitinib (PLB-1001)
StdInChI
CN1C=C2C=C(C(F)=CC2=N1)C(F)(F)C1=NN=C2C=CC(=NN21)C1=CN(N=C1)C1CC1
StdInChIKey
InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3
Molecular Formula
C20H15F3N8
Molecular Weight
424.382
Properties
Structure
Structure of PLB-1001 CAS 1440964-89-5
Safety Data
Symbol
Signal Word
Warning
WGK Germany
3
MSDS Download
Specifications and Other Information of Our
Water
Loss on Drying
Residue on Ignition
Single Impurity
Total Impurities
Shelf Life
2 years
Storage
Store at -20°C and away from light
Known Applicationc
Bozitinib is a receptor tyrosine kinase inhibitor targeting the cell-mesenchymal-epithelial transition factor (c-MET), capable of inhibiting the proliferation of tumor cells with elevated c-MET expression. This drug can penetrate the blood-brain barrier and has been registered for 8 clinical trials domestically, with indications including non-small cell lung cancer (NSCLC), gliomas, and more.
General View of Documents
Links
This product is developed by our R&D company Caming Pharmaceutical Limited (http://www.caming.com/).
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