- Identification

- Properties

- Safety Data

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Identification

CAS Number

738-70-5

Name

Trimethoprim

Synonyms

2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine2,4-Pyrimidinediamine, 5-- 212-006-2 5-(3,4,5-Trimethoxybenzyl)-2,4-pyrimidindiamin  5-(3,4,5-Trimethoxybenzyl)-2,4-pyrimidinediamine 5-(3,4,5-Triméthoxybenzyl)-2,4-pyrimidinediamine  5-(3,4,5-Trimethoxybenzyl)pyrimidin-2,4-diamin 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine5-(3,4,5-triméthoxybenzyl)pyrimidine-2,4-diamine 5-{methyl}pyrimidine-2,4-diamine625127 738-70-5 Instalac MFCD00036761 Monotrim Proloprim Syraprim TCMDC-125538Tiempe Trimanyl Trimethoprim     Trimethoprime Trimethoprimum Trimetoprim Trimetoprima Trimogal Trimopan Trimpex Triprim Uretrim UV8225000WELLCOPRIM триметоприм  ثلاثي ميثوبريم  甲氧苄啶  Abacin AlprimBactinBaktar ChemotrimComoxCotrim D.S.Drylin eusaprim Fectrim GantaprimGantrim IdotrimImexim Kepinol Laratrim Linaris MethoprimMicrotrim Nopil OraprimPriloprimPrimoseptPrimsolSeptrin Sigaprim Sulfotrim Sulprim Sumetrolim Supracombin Suprim Teleprim Thiocuran Tmp-RatiopharmTrigonyl Trimesulf TrimethioprimTrimethopriomTrimexazoleUnitrimUroplusUro-Septraamine1-(2,3,4-Trimethoxybenzyl)piperazine 1189460-62-5 2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidi2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)-p

SMILES

COc1cc(cc(c1OC)OC)Cc2cc(=N)c2=N

StdInChI

InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

StdInChIKey

IEDVJHCEMCRBQM-UHFFFAOYSA-N

Molecular Formula

C14H18N4O3

Molecular Weight

290.318

EINECS

212-006-2

Beilstein Registry Number

625127

MDL Number

MFCD00036761

Properties

Appearance

White Specifications or yellowish white powder

Melting Point

Between 199-203°C

Safety Data

Symbol

GHS06, GHS08

Signal Word

Danger

Hazard statements

H301 - H361d

Precautionary Statements

P202 - P264 - P270 - P280 - P301 + P310 - P405

WGK Germany

3

Specifications and Other Information of Our

Identification Methods

HNMR, HPLC

Infrared Absorption Spectrophotometry

The infrared absorption specturm of sample is concordant with the spectrum of trimethoprim RS

Ultraviolet Visible

Calculate absorptivities, on the dried basis for the at test sample only, at the wave length of maximum absorbance at about 287 min do not differ by MT 3%

Purity

98% min

Loss on Drying

NMT 0.5% w/w

Residue on Ignition

NMT 0.1% w/w

Single Impurity

Impurity-A

NMT 0.1% w/w

Impurity-B

NMT 0.1% w/w

Impurity-C

NMT 0.1% w/w

Impurity-D

NMT 0.1% w/w

Impurity-E

NMT 0.1% w/w

Impurity-F

NMT 0.1% w/w

Impurity-G

NMT 0.1% w/w

Impurity-J

NMT 0.1% w/w

Impurity-K by GC

NMT 5ppm

Total Impurities

NMT 0.2% w/w

Shelf Life

5 years

Storage

Under room temperature away from light

Known Application

Trimethoprim is a lipophilic weakly basic pyrimethamine bacteriostatic agent, also known as sulfa synergist, trimethoprim, antibacterial synergist, trimethoprim, trimethoprim, trimethoprim Omethoprim, trimethoprim, white or off-white crystalline powder at room temperature, odorless, bitter, slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water, easily soluble in glacial acetic acid dissolve. The antibacterial spectrum is similar to that of sulfa drugs, but the antibacterial effect is stronger. It is effective against Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus Chemicalbook, and various Gram-positive and negative bacteria, but it is ineffective against Pseudomonas aeruginosa infection and has the lowest antibacterial effect The concentration is usually lower than 10mg/L, and it is easy to cause bacterial resistance when used alone. Therefore, it is generally not used alone. It is mainly composed of compound preparations with sulfonamides. It is clinically used to treat urinary tract infections, intestinal infections, respiratory infections, bacillary dysentery, Enteritis, typhoid fever, meningitis, otitis media, meningitis, sepsis and soft tissue infection. The curative effect on typhoid and paratyphoid is not lower than that of ampicillin, and it can also be used in combination with long-acting sulfa drugs for the prevention and treatment of drug-resistant falciparum malaria.

Links

This product is developed by our R&D company Caming Pharmaceutical Limited (http://www.caming.com/).

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