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Identification

CAS Number

68538-85-2

Name

Levofolinic acid

Synonyms

(6S)-5-formyltetrahydrofolic acid68538-85-2 Acide N-méthyl}amino)benzoyl]-L-glutamique LevoleucovorinL-Folinic acidL-Glutamic acid, N-methyl]amino]benzoyl]- N-methyl}amino)benzoyl]-L-glutamic acid N-methyl}amino)benzoyl]-L-glutaminsäure (2S)-2-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid(2S)-2-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid(2S)-2-methylamino]benzoyl]amino]glutaric acid(2S)-2-methylamino]benzoyl]amino]pentanedioic acid(2S)-2-methylamino]phenyl]carbonylamino]pentanedioic acid(2S)-2-methylamino]benzoyl]amino]glutaric acid(2S)-2-METHYLAMINO]BENZOYL]AMINO]PENTANEDIOIC ACID(2S)-2-methylamino]benzoyl]amino]pentanedioic acid(2S)-2-methylamino]phenyl]carbonylamino]pentanedioic acid(2S)-2-{methyl}amino)phenyl]formamido}pentanedioic acid(2S)-2-{methyl}amino)phenyl]formamido}pentanedioic acid(2S)-2-{methyl}amino)phenyl]formamido}pentanedioic acid(6R,S)-5-Formyltetrahydrofolate(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid; (6S)-5-formyltetrahydrofolic acid; (6S)-Folinic acid; (6S)-Leucovorin; (S)-Leucovorin; Citrovorum factor; L-Folinic acid; Levofolene; Levofolinic acid; N-methyl}amino)benzoyl]-L-glutamic acid(6S)-5-formyltetrahydrofolate(6S)-5-HCO-H4folate(6S)-Folinic acid(6S)-Leucovorin(S)-Leucovoringlutamate10-formyl-7,8-dihydrofolate10-Formyl-7,8-dihydrofolic acid121451-09-0 1492-18-8 200-361-6 58-05-9 5-CHO-H4PteGlu15-FORMYL-5,6,7,8-TETRAHYDROFOLATE5-Formyl-5,6,7,8-tetrahydrofolic acid5-FORMYL-6-HYDROFOLIC ACID5-Formyltetrahydrofolate5-formyltetrahydrofolic acid5-Formyltetrahydropteroylglutamate5-Formyltetrahydropteroylglutamic acid6R-Leucovorin73951-54-9 Antianemia factorApo-folicCitrovorum factorCitrovorum factor; Folinic acid; L-leucovorin; LevoleucovorinFFOfolinate folinic acid Folinic acid calcium saltFolinic acid-SFFusilevL(-)-5-Formyl-5,6,7,8-tetrahydrofolic acidLeucalLeucovorin LevofoleneLevofolinic acidL-Glutamic acid, N-(4-((((6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-Glutamic acid, N-(4-((((6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, (S)-L-leucovorinMission PrenatalMittafolMVC PLUSN-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acidN-methyl}amino)benzoyl]-L-glutamic acidN-methyl}amino)benzoyl]-L-glutamic acidN-amino]benzoyl]-D-Glutamic acidN5-Formyl-5,6,7,8-tetrahydrofolateN5-Formyl-5,6,7,8-tetrahydrofolic acidn5-formyltetrahydrofolateN5-Formyltetrahydrofolic acidNifolinNovofolacidNovo-folacidN-Pteroyl-D-glutamic acidPteroyl-D-glutamatePteroyl-D-glutamic acidPteroylmonoglutamateUNII-Q573I9DVLPUzel Uzel (Trade name)Uzel; WellcovorinVitamin B11VITAPEDWelcovorinWellcovorin

SMILES

c1cc(ccc1C(=O)N(CCC(=O)O)C(=O)O)NC2CNc3c(c(=O)nc(3)N)N2C=O

StdInChI

InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1

StdInChIKey

VVIAGPKUTFNRDU-STQMWFEESA-N

Molecular Formula

C20H23N7O7

Molecular Weight

473.439

EINECS

200-361-6

Properties

Appearance

Yellowish to yellow powder, odorless

Safety Data

RIDADR 

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Levofolinic acid CAS 68538-85-2

Identification Methods

HNMR, HPLC

Assay

97.0% - 102.0% on the anhydrous basis

Hygroscopicity

< 0.2%

Specific Optical Rotation

-11° to -16°

pH

3.5-4.5

Clarity

Solution should be clarity

Chlorides

≤ 0.5%

D-Leucovorin

≤ 0.5%

Heavy Metals

≤ 20ppm

Water

≤ 2.0%

Residue on Ignition

≤ 0.5%

Related Substances (I)

Impurity A

≤ 0.2%

Impurity E

≤ 0.2%

Impurity F

≤ 0.2%

Other single impurity

≤ 0.2%

Total Impurities

≤ 1.5%

Related Substances (II)

ZYG03≤ 0.6%

Ca

≤ 0.1%

Bacterial Endotoxin

< 1.0EU/mg

Microbial Limit

TAMC

≤ 1000cfu/g

TYMC

≤ 100cfu/g

E. Coli.

Absent in 1g

Shelf Life

2 years

Storage

Store at room temperature, sealed and away from light.

Known Application

Commonly used as impurity reference.

Links

This product is developed by our R&D company Caming Pharmaceutical Ltd (https://www.caming.com/).

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