IdentificationPropertiesSafety DataSpecifications and Other InformationLinks
Identification
CAS Number
82186-71-8
Name
Halofuginon Lactate
Synonyms
2-Hydroxypropanoic acid - 7-bromo-6-chloro-3-{3--2-oxopropyl}-4(3H)-quinazolinone (1:1) 2-Hydroxypropansäure --7-brom-6-chlor-3-{3--2-oxopropyl}-4(3H)-chinazolinon (1:1) Acide 2-hydroxypropanoïque - 7-bromo-6-chloro-3-{3--2-oxopropyl}-4(3H)-quinazolinone (1:1) Propanoic acid, 2-hydroxy-, compd. with 7-bromo-6-chloro-3--2-oxopropyl]-4(3H)-quinazolinone (1:1) 2-Hydroxypropanoic acid 7-bromo-6-chloro-3--2-oxo-propyl]quinazolin-4-one7-bromo-6-chloro-3--2-oxo-propyl]quinazolin-4-one;2-hydroxypropanoic acid7-bromo-6-chloro-3--2-oxopropyl]quinazolin-4-one7-bromo-6-chloro-3--2-oxopropyl]quinazolin-4-one and 2-hydroxypropanoic acid82186-71-8 Halofuginone lactateHalofuginone lactate 100 ?g/mL in AcetonitrileHalofuginone lactate 100 µg/mL in Acetonitrile - short expiry, for immediate use only
SMILES
CC(C(=O)O)O.c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)C3(CCCN3)O
StdInChI
InChI=1S/C16H17BrClN3O3.C3H6O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;1-2(4)3(5)6/h5-6,8,14-15,19,23H,1-4,7H2;2,4H,1H3,(H,5,6)/t14-,15+;/m0./s1
StdInChIKey
GATQERNJKZPJNX-LDXVYITESA-N
Molecular Formula
C19H23BrClN3O6
Molecular Weight
504.76
Properties
Appearance
Off-white to white solid
Safety Data
WGK Germany
3

MSDS Download

SDS of Halofuginon Lactate CAS 82186-71-8Download

Specifications and Other Information of Our Halofuginon Lactate CAS 82186-71-8
Standard
Enterprise standard
Identification Methods
HPLC/HNMR
Purity
97%min

Related substances

cis-Halofuginone Lactate

≤2.0%

Total inpurities

≤3.0%

Loss on drying

≤1.0%

Shelf life

2 years

Package
According to customer requirements to packaging
Storage
Store in a cool and dry place.
Application
Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders.Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.

General View of Documents

HPLC of Halofuginon Lactate CAS 82186-71-8

IR of Halofuginon Lactate CAS 82186-71-8

Links
This product is developed by our RandD company Caming Pharmaceutical Ltd(http://www.caming.com/), and here is the corresponding linkhttp://www.caming.com/halofuginon-lactate-cas-82186-71-8/
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